The Arsenal forward has produced a goal or an assist in all four of his appearances at Emirates Stadium this season.
The underlying statistics highlight his attacking potential.
At home, no Gunners player has bettered the Frenchman's 12 shots inside the penalty area or his total of eight shots on target.
Lacazette looks well-placed to punish a Southampton side who have conceded 23 goals in the last seven Gameweeks.
He takes his place in a Scout Selection which lines up in a 3-4-3 formation, with Liverpool's Sadio Mane (£12.1m) handed the armband and Jamie Vardy (£9.6m) of Leicester City given the vice-captaincy.
A home contest with Newcastle United makes the Frenchman a strong, cut-price candidate. Guilbert has delivered attacking or defensive returns in four of his five appearances at Villa Park.
The South Korean can continue his impressive away form in Tottenham Hotspur's first match under Jose Mourinho. Son visits West Ham United having produced attacking returns in four of his five appearances on the road this season.
At home, the Brazilian's 15 shots in the box are more than double any other Everton player. He can punish a Norwich defence who have conceded 28 goals in the opening 12 Gameweeks. The Canaries have also recorded a clean sheet on only one occasion in 2019/20.
At home, the Scot's 19 shots and seven shots on target are more than any other Aston Villa player. McGinn comes up against a Newcastle defence who have conceded a league-leading 14 away goals.
The top-scoring midfielder in FPL, Mane has a fine record against Crystal Palace. He has found the net in each of his last four Premier League meetings with the Eagles.
An ownership of only 1.7 per cent highlights the Frenchman's potential as a major differential for the Gameweek 13 armband.
Eight goals and two assists in the last six Gameweeks have lifted the in-form Leicester forward to the top of the FPL player standings. More than 419,000 managers have bought Vardy ahead of the Foxes' visit to Brighton & Hove Albion.
Sam Bonfield (@FPLFamily): Wow, what a team this is! I must admit my first reaction was, "Why isn't Vardy captain?" but the Mane v Palace stats look amazing. Richarlison looks a great one-week punt pick; with three returns in the last four and playing out of position as a striker he should return good points this weekend.
Holly Shand (@FFCommunity_): Son could be a great differential now with the new manager bounce! I'm expecting Richarlison to do well against Norwich.
Ash (@FPLHints): Jimenez is a good shout for Gameweek 13 and the weeks ahead once UEFA Europa League football pauses until the spring. I also think McGinn could replicate same of his international form against Newcastle on Monday night.
Lee Bonfield (@FPLFamily): I'm keeping a close eye on Son and the impact Mourinho has on him. It might just be a week early after the international fixtures, though.
Neal Thurman (@nealjthurman): Palace have been tough defensively and going to Selhurst Park has been a tough assignment, so Vardy at Brighton seems much more conducive to a multiple-goal return.
Ben Crabtree (@FC_CrabDogg): Double Everton is a rarity but the fixture justifies it. Both players are differentials of great potential this week.
Ben McNair (@drbenmcnair): I like the Aston Villa and Everton double-ups given their home fixtures against Newcastle and Norwich. But I would have found room for Lucas Digne (£5.9m) and, if he's passed fit, Jack Grealish (£5.9m), since they are the main creators for their respective teams. I'm also surprised at the omission of Raheem Sterling (£12.0m) as I don't think Chelsea will be able to handle Manchester City at the Etihad Stadium.