Sixth-placed Arsenal are seeking their first win in five matches after slipping eight points outside the top four.
Southampton, who are one point off the foot of the table, are aiming to halt a three-match losing streak.
Sead Kolasinac has a slight hamstring problem and will be assessed by the Arsenal medical team ahead of Saturday's match.
Dani Ceballos (hamstring) is unavailable and targeting a mid-December return to full training.
Southampton manager Ralph Hasenhuttl has no fresh injury concerns following the international break.
Ryan Bertrand has completed a three-match suspension and is in included in a full-strength squad.
Arsenal are unbeaten in their last 24 home league matches against Southampton (W18 D6), since November 1987.
The Gunners have won their last 32 Premier League home matches against sides starting the day in the relegation zone. Their last such defeat came against West Ham United in April 2007.
Seven of the eight points earned by Southampton this season, or 88 per cent, have come in away matches.
Saints’ Danny Ings has scored in five Premier League matches this season but is yet to win any of them (D1 L4).
Referee: Stuart Attwell. Assistants: Richard West, Neil Davies. Fourth official: Gavin Ward. VAR: Andy Madley. Assistant VAR: Eddie Smart.