Southampton are targeting a second win in a row after beating Brighton & Hove Albion, while Manchester United are aiming to bounce back from their home defeat by Crystal Palace.
Southampton manager Ralph Hassenhuttl expects Nathan Redmond to be out for two or three weeks with an ankle injury sustained during Tuesday's EFL Cup win over Fulham.
Moussa Djenepo has also been ruled out of this weekend's match with a muscle problem, while Michael Obafemi is likely to miss out due to cramp.
Man Utd duo Anthony Martial and Luke Shaw are out of action after picking up knocks. Martial could return after the international break but Ole Gunnar Solskjaer believes Shaw may need an extra week or two.
Defender Diogo Dalot remains sidelined, along with long-term absentees Eric Bailly and Timothy Fosu-Mensah, but is expected to be fit after the international break.
The home team have won just three of the last 15 Premier League meetings between these sides (W3 D5 L7).
There have been seven goals from direct free-kicks in PL fixtures between these teams, including two by Southampton last season. There have only been more in total in matches between Liverpool and Man Utd, with eight.
Southampton's Nathan Redmond has been directly involved in four goals in his last four PL home matches, providing three goals and an assist.
In all competitions, Man Utd have won more away matches at St Mary's against Southampton than any other side, with 10 victories.
Referee: Mike Dean. Assistants: Darren Cann, Daniel Robothan. Fourth official: Simon Hooper. VAR: Michael Oliver. Assistant VAR: Stephen Child.