The Everton winger, down as a midfielder in FPL, scored in this fixture last season and is part of this week's Scout Selection.
Richarlison thrived at home in 2018/19. He was Everton's joint-top scorer at Goodison Park with seven goals, along with Gylfi Sigurdsson (£8.0m).
But the Brazilian offered a greater threat inside the penalty area. His total of 40 shots was top for Everton, bettering the 32 of Sigurdsson.
His average of 6.4 points per match in 2018/19 was more than any other defender in FPL. Alexander-Arnold is seeking an assist for the sixth Premier League match in a row as Liverpool travel to Southampton.
The left-back’s four goals, five assists and 13 clean sheets last season underline his all-round potential. Digne scored in the corresponding fixture last term and could even be an outside pick for the captain's armband.
As the most-owned midfielder or forward in FPL, Salah is expected to remain the top captain pick for Gameweek 2. He has a fine record against Southampton, scoring in all four of their meetings.
The Brazilian will hope to take advantage of the defensive vulnerability displayed by a Watford side who lost 3-0 at home to Brighton in their opening match.
A major target in the budget midfield bracket after his Gameweek 1 goal against Spurs. McGinn has earned over 140,000 new owners for a home meeting with AFC Bournemouth.
The Arsenal forward is a key captain pick in Gameweek 2 for the visit of Burnley. Aubameyang has scored two goals in each of his three meetings with the Clarets.
Holly Shand (@FFCommunity_): Aubameyang is the best captain pick if you have him. Henderson and Montoya could be great shouts for a differential clean sheet.
Tom (@WGTA_FPL): A good team with an interesting mix. Richarlison in particular catches my eye, owned by under 10 per cent of managers with the explosive potential to hurt Watford.
Ash (@FPLHints): Pukki and McGinn are viable differential picks if you are short of cash in midfield and up top. As for the captain, I favour Aubameyang with his favourable fixture and with Salah's midweek UEFA Super Cup exertions in mind.
Josh Landon (@hailcheaters): After a strong showing at AFC Bournemouth, Sheffield United's defence looks capable of holding their own. Henderson, a good short-term replacement for Alisson (£5.9m) is a strong pick ahead of nice run of fixtures.
Sam Bonfield (@FPLFamily): McGinn deserves his place after he scored and passed the eye test in Gameweek 1. With Aubameyang’s record against Burnley, he looks a great pick.
Mark McGettigan (@FPLGeneral): If I owned Aubameyang, I'd give him the armband after Salah's 120 minutes in midweek. I would have opted for Sigurdsson over Richarlison and fancy Pukki to do some damage against Newcastle.
Chuck Booth (@ChuckBoothSport): Happy to see Montoya included. I like the Brighton defence, along with his attacking potential. But it is a week early as the match against West Ham will have goals.
Ben McNair (@drbenmcnair): Watford's expected-goals-conceded metric has been climbing over the past 12 months, so Richarlison could do well this week. But, I would have picked Sigurdsson for his set-piece responsibilities.