Arsenal won the U18 Premier League South last season before losing 5-2 to Derby County, the winners of the North Division, in the national final.
And their bid to go one step further will begin with a home match against the U18 PL champions in 2016/17 and 2017/18 in a full round of fixtures on the opening day.
Derby, who also qualified for the UEFA Youth League by winning the title, will start their defence with a trip to Everton.
Sync the U18 fixtures to your mobile device by using the Premier League's digital calendar.
11:00 Blackburn v Liverpool
11:00 Newcastle v Middlesbrough
11:00 Stoke v Wolves
11:30 Everton v Derby
11:30 West Brom v Man City
12:30 Man Utd v Sunderland
11:00 Arsenal v Chelsea
11:00 Fulham v Spurs
11:00 West Ham v Swansea
12:00 Brighton v Reading
12:00 Leicester v Norwich
12:30 Southampton v Aston Villa