History shows that Man Utd are the Premier League team to fear facing most on the opening weekend.
They are the kings of Matchweek 1, having won an impressive 18 of their 27 opening fixtures.
That is the best record for clubs who have played at least four Premier League matches.
United sit narrowly ahead of the 2.11 average of their opening opponents, Chelsea, who started last season with a 3-0 win at Huddersfield Town.
Promoted Sheffield United have averaged 2.33 points on the opening weekend but have only taken part in three previous Premier League campaigns.
Southampton have won only two of their 20 Matchweek 1 fixtures, both of which came away from home.
Saints will be hoping to add a third opening-weekend victory when they kick off the new campaign at Burnley.
Graham Potter's Seagulls face the Hornets again and will hope to improve on their first Premier League match last season, a 2-0 defeat at Vicarage Road.
*The 2011/12 opening-day fixture between Spurs and Everton was postponed