History shows that Man Utd are the Premier League team to fear facing most on the opening weekend.
They are the kings of Matchweek 1, having won an impressive 18 of their 27 opening fixtures.
That is the best record for clubs who have played at least four PL matches.
United sit narrowly ahead of the 2.11 average of their opening opponents, Chelsea, who started last season with a 3-0 win at Huddersfield Town.
Promoted Sheffield United have averaged 2.33 points on the opening weekend but have only taken part in three previous PL campaigns.
Southampton have won only two of 20 Matchweek 1 fixtures, both of which came away from home.
Saints will be hoping to add a third opening-weekend victory when they kick off the new campaign at Burnley.
Graham Potter's Seagulls face the Hornets again hoping to improve on their first PL match last season, a 2-0 defeat at Vicarage Road.
*The 2011/12 opening-day fixture between Spurs and Everton was postponed
Remember, fans can get all 380 fixtures sent directly to their mobile devices in real time by using the Premier League's digital calendar, which can be set up right now.