Relegated Huddersfield Town are seeking to avoid a ninth straight defeat.
Manchester United, who lie three points outside the top four in sixth place, are looking for a first win in four Premier League matches.
Jan Siewert has hinted that Adama Diakhaby may feature for Huddersfield, while Aaron Mooy (hip) returned to training this week.
Zanka (cold) will be assessed and Ben Hamer is back in training but not match-fit.
Man Utd are without Eric Bailly (knee) for the last two matches of the season and Mason Greenwood has been ruled out, but Marcus Rashford (shoulder) could be available.
Sergio Romero faces a fitness test after tweaking his knee in training.
While Huddersfield have only won one of their last 13 top-flight meetings with Man Utd, that victory came in this fixture last season (2-1).
The Terriers need one goal on Sunday to avoid becoming the first ever top-flight team to fail to reach 10 goals at home in a campaign.
Man Utd are looking to win their last PL away match of the season for the first time since 2011/12, having since drawn five of those fixtures and lost one.
Romelu Lukaku has scored 12 PL goals this season, the most of any player who is yet to provide an assist in the competition.
Referee: Lee Mason
Assistants: Harry Lennard, Scott Ledger
Fourth official: Mike Dean