Sergio Aguero's (£13.1m) 43.4% of Fantasy Premier League owners are left anxiously awaiting developments after he sustained a calf problem during training for Argentina.
Aguero has averaged more FPL points per match (7.8) than any forward this season but is considered a doubt for Wednesday morning's encounter with Paraguay.
The 20-year-old - who scored in Nigeria’s weekend win over Zambia - produced a goal and assist in both his appearances in the starting XI when filling in for Aguero over Gameweeks 4 & 5.
Romelu Lukaku (£9.4m) is also an injury worry for FPL managers after limping out of Belgium's victory over Bosnia-Herzegovina.
Residing in 22.2% of squads, the Everton forward was amongst the scorers in a 4-0 win but sustained a minor thigh problem and will assessed prior to Monday evening's clash against Gibraltar.
There's no such concern for Diego Costa (£10.1m), who continues to attract new FPL investors after notching in Spain's 2-0 defeat of Albania 2-0 on Sunday.
The top-scoring forward in FPL, Costa has already been drafted into 98,000+ squads ahead of Gameweek 8.
Meanwhile, Costa's team-mate Eden Hazard (£9.9m) is showing signs of recovery. He brushed aside a four-Gameweek drought by supplying a goal and assist in Belgium’s win on Friday.
Tottenham Hotspur's Toby Alderweireld (£6.5m) also scored in the same fixture, underlining his goal threat from set-plays.
Alderweireld has produced eight attempts inside the box this season - Crystal Palace's Scott Dann (£5.4m) is the only defender to register more.
His White Hart Lane team-mate Dele Alli (£8.2m) found the net in England's 2-0 win over Malta. Alli has picked up in form after a slow start to the season, producing points in three of the last four Gameweeks.
Dimitri Payet (£9.4m) is another midfielder to maintain form over the internationals as he scored in France's 4-1 victory over Bulgaria on Friday evening.
The playmaker has produced a goal and four assists in four Premier League starts for West Ham United.
But Southampton midfielder Dusan Tadic (£7.2m) has been the star turn on show so far over the break and he turned in another superb performance in Serbia's 3-2 win over Austria on Sunday.
He supplied the assists for the first two strikes before firing a late winner, meaning he has played a part in all six of Serbia's goals over their two qualifiers.
Tadic has produced FPL points in three of the last four Gameweeks ahead of Sunday's encounter with Burnley.