The Tottenham Hotspur striker has quickly found his form since returning from injury, scoring in three of his last four matches in all competitions.
Kane’s threat on the road will trouble Saints on Saturday afternoon.
He has scored 10 away goals in 2018/19, more than any other player.
And the 25-year-old's underlying statistics further strengthen his bid for the captaincy in FPL.
Away from home, his 51 shots and 37 shots inside the penalty area are both league-leading figures.
Lacazette has scored in each of the Gunners’ last five Premier League home matches.
Meanwhile, Lukaku has scored twice in three successive matches in all competitions for United. Yet he remains a huge differential, owned by only 4.7 per cent of FPL managers.
Vardy has scored in three of the last four Gameweeks and faces a side whose 65 conceded goals are the highest in the division.
Hazard has produced four double-digit hauls at home this season, including a 15-point return against Huddersfield Town in Gameweek 25.
Higuain has recorded three goals and 25 points over the last four Gameweeks.