Leaders Manchester City are looking for a third straight victory, while Chelsea are aiming to build on their 5-0 triumph over Huddersfield Town.
Man City will be without defender Benjamin Mendy (knee) and Vincent Kompany (muscular).
Chelsea's Callum Hudson-Odoi has recovered from illness and both he and Gary Cahill (back) are expected to be among a full complement of players for Maurizio Sarri.
Man City can set a PL record by scoring at least twice in a 15th successive home match. They are currently tied on 14 with Liverpool, who achieved that feat in 2013/14.
Pep Guardiola has lost three league matches against Chelsea, more than against any other team in his managerial career.
Chelsea are unbeaten in seven PL fixtures against reigning PL champions and can now become only the third team to win four such matches in a row, after Liverpool and Man City.
The Blues, who won the reverse fixture this season, have done the double over Man City on 10 occasions in the Premier League, more than any other side.
Referee: Mike Dean
Assistants: Darren Cann, Dan Robathan
Fourth official: Paul Tierney