Manchester City were unable to convert dominant possession into goals as they were held to a goalless draw by Southampton.
The home side controlled much of the first half and came closest to scoring through Ilkay Gundogan and Raheem Sterling.
Southampton were awarded a penalty on 61 minutes, when Kyle Walker was adjudged to have fouled Adam Armstrong, for which he was shown a red card.
However, both decisions were overturned after a review by referee Jonathan Moss.
City thought they had a stoppage-time winner when Phil Foden's saved header, their only shot on target throughout the match, was converted by Sterling on the rebound.
But Sterling was found to have been offside
A first draw in 31 league matches puts Man City second on 10 points, while Southampton, still awaiting a first win, drop to 15th with four points.
Man City: 25 Sep v Chelsea (A)
Southampton: 26 Sep v Wolves (H)
Referee: Jonathan Moss. Assistants: Marc Perry, Timothy Wood. Fourth official: Peter Bankes. VAR: Martin Atkinson. Assistant VAR: Richard West.