Liverpool can extend their unbeaten home run to 60 matches having not lost at Anfield since April 2017.
Leeds United will play a Premier League fixture for the first time in 16 years.
Team news
Liverpool will make a late call on the availability of Jordan Henderson, Xherdan Shaqiri and Kostas Tsimikas.
Marcelo Bielsa has a near fully fit squad available with long-term absentee Adam Forshaw (hip) the only confirmed absentee for the visit to Anfield.
Did you know?
Mohamed Salah can be the first Liverpool player to score in Matchweek 1 in four consecutive PL seasons.
Since a 2-1 Premier League defeat in April 2001, Liverpool are unbeaten in their last eight meetings against Leeds in all competitions.
Leeds have not lost any of their 12 opening-weekend PL matches, the best unbeaten MW1 record in the competition.
Marcelo Bielsa will be the second-oldest permanent post-war manager after Dick Advocaat to take charge of his first match in the English top flight, aged 65 years and 53 days.
Match officials
Referee: Michael Oliver (pictured). Assistants: Stuart Burt, Simon Bennett. Fourth official: Mike Dean. VAR: Paul Tierney. Assistant VAR: Andy Halliday.