Crystal Palace goalkeeper Steve Mandanda will this week have a knee operation and be out for around six weeks.
Connor Wickham (knee) could miss the rest of the season and Yohan Cabaye is suspended. Loic Remy (calf), Jonathan Benteke (knee) and Pape Souare (thigh) are injured.
Southampton midfielder Dusan Tadic is still out with a broken nose and Matt Targett is not yet fit.
Did you know?
Crystal Palace’s only Premier League win over Southampton came in last season’s meeting at Selhurst Park (W1 D4 L9).
Saints have conceded just three goals in their last six Premier League meetings against Crystal Palace, keeping three clean sheets.
Alan Pardew has lost four of his last five Premier League encounters against Southampton (W1).
Charlie Austin’s six Premier League goals in 2016/17 have won Saints six points. Only Sergio Aguero (eight) and Diego Costa (seven) have earned their teams more PL points this season.
What the managers say
Alan Pardew: "The fans travelled to Burnley, Swansea - games we should have won. We need to pay them back."
See: Palace preview
Claude Puel: "It was an objective of the team to progress to the [EFL Cup] semi-finals. Now we need to keep our level in the Premier League."
See: Tadic update