Burnley manager Owen Coyle accepts "it does not come any tougher" after seeing fixtures for the new campaign.
The Clarets returned to the top flight of English football for the first time since 1976 after beating Sheffield United 1-0 in the Championship play-off final at Wembley.
On the opening day, the Lancashire side kick off at Stoke City before facing a run of four successive matches against teams from last season's top five.
Burnley's first home fixture in the Barclays Premier League is a mouth-watering meeting with champions Manchester United on Tuesday 18th August.
They then face a home match against Europa League qualifiers Everton ahead of travelling to Chelsea on 29th August and then Liverpool away on 12th September.
no illusions
Coyle said: "What a fantastic start to have. It does not come any tougher and we are under no illusions about how difficult it will be.
"But it is fantastic that we are even talking about it in same breath as Burnley Football Club and we aim to make the most of it. We know what it is about and we will be ready to give it our best."
After such a long wait for a chance to take on the best England has to offer, Coyle feels the Clarets' passionate fans can make a difference.
"I think we are the smallest town ever to play in the Premier League - when Manchester United play at home there's more people at Old Trafford than in the whole town. So we know how big the gap is, but it is a challenge we are looking forward to," he said.
"We had a terrific home record last season and we have seen with the season tickets the level of expectation already.
"The fans played a part last year and we hope that continues - it is a terrific footballing environment to come in to and there is a tremendous tradition at Burnley.
"I think the atmosphere at the club is conducive to that and on the back of that we want to try and pick up some points."