Those who came to Griffin Park on Friday night were treated to a first appearance in a Chelsea shirt for summer signing Marko Marin.
The Germany winger, who joined from Werder Bremen, continued his rehabilitation from injury but was unable to prevent Chelsea U21s from going down to a 4-1 defeat by Liverpool.
The visiting side also fielded a summer signing from the Bundesliga in Yesil, who was bought from Bayer Leverkusen.
After edging a goalless first half but Liverpool took the lead midway through the second with a header from Jack Robinson which was doubled a few minutes later with a penalty from Conor Coady.
Chelsea had hopes of getting something from the game when Patrick Bamford scored in the 80th minute but instead Krisztian and Michael Ngoo were on target.
Full report here
A second-half strike from Sam McQueen condemned Newcastle United to their first defeat of the season at Whitley Park and sent Southampton top of Group 2.
One positive for Newcastle was that Sammy Ameobi played a full match as he recovers from a hamstring injury suffered in a pre-season match.
Newcastle reaction and gallery.
Full report here.
Grzegorz Sandomierski and Nuno Henrique played their first matches for Blackburn Rovers but were unable to get past Bolton in a goalless stalemate at Ewood Park.
The closest to a goal came in the 51st minute when Henrique's header was well saved and Blackburn could not convert during the subsequent goalmouth scramble.
Full report here
There was also a draw in the final Friday match where Reading were held 1-1 at home to Everton.
Matt Partridge put the home side ahead on 21 minutes but the lead was cancelled before half-time with a powerful header from Everton defender Shane Duffy.
Full report here.
Friday, September 14th
GROUP 1
Blackburn Rovers 0-0 Bolton Wanderers, Ewood Park
Reading 1-1 Everton, Hogwood Park
GROUP 2
Newcastle United 0-1 Southampton, Northumberland FA
GROUP 3
Chelsea 1-4 Liverpool, Brentford FC
Sunday, September 16th
GROUP 1
West Bromwich Albion v West Ham United, The Hawthorns (2pm) (Ticket information here)
Monday, September 17th
GROUP 1
Arsenal v Norwich City, Barnet FC (7pm) Tickets: Free Directions
GROUP 2
Tottenham Hotspur v Stoke City, TBC, 12pm
GROUP 3
Fulham v Middlesbrough, Motspur Park (7pm) Directions
Wolverhampton Wanderers v Crystal Palace , AFC Telford United (7pm) (More information here)
Tuesday, September 18th
GROUP 2
Newcastle United v Sunderland, Sports Direct Arena (7pm) Ticket info to come
For all Barclays U21 Premier League news, results and tables click here
You can follow developments on Twitter with the Premier League's account @premierleague or via the hashtag #BU21PL
