James Chester's goal and a late Allan McGregor penalty save earned Hull City a 1-0 win and spoiled Queens Parl Rangers' return to the Barclays Premier League.
Having dropped out of the top flight in 2012-13, Harry Redknapp's men bounced back at the first attempt last season courtesy of a 1-0 win in the Championship play-off final against Derby County.
Indeed the hosts were the better team in the first half at Loftus Road, but failed to build on their good start as Steve Bruce's side clinched a narrow victory, McGregor denying Charlie Austin from the spot with five minutes to play.
Chester's goal arrived shortly after the interval, the centre-half proving too strong for QPR debutant Rio Ferdinand and glancing in Stephen Quinn's right-wing corner.
After their run to the FA Cup final last season, Hull also have Europe to contend with, and came into the game with competitive action already under their belts this term, but Bruce's priority will remain the Barclays Premier League.
With that in mind, the former Sunderland manager will have been enthused by his side's ability to seal all three points after struggling to cause QPR many problems in the first period.
Both sides started with three new faces as Ferdinand, Steven Caulker and Jordon Mutch all made their competitive bows for QPR, while Robert Snodgrass, Tom Ince and Andrew Robertson were Hull's BPL debutants.
After an assured start from the visitors, the hosts grew into the game and had the first effort of note in the 17th minute when Alejandro Faurlin dragged a shot narrowly wide following a scramble inside the Hull penalty area. Joey Barton and Mutch then both went close as QPR continued to look the more likely to break the deadlock.
Hull's struggles to create chances were dealt a further blow as Snodgrass was forced off with a knee injury five minutes before the break and replaced by Quinn.
And they had Robertson to thank for heading in at the break level after the Scotland international scrambled Caulker's header off the line, with McGregor pawing the rebound away.
Seven minutes after the break Chester put Hull in front, getting the better of Ferdinand and heading Quinn's corner into the bottom left-hand corner from eight yards.
Quinn was influential again 10 minutes later as he led a breakaway and played in Ince, but the England Under-21 international was denied by the legs of Rob Green one-on-one.
Hull survived two late scares in the final 10 minutes as QPR searched desperately for an equaliser.
First, Tom Huddlestone hacked the ball off the line after it had bounced goalwards off the knee of Ferdinand.
Then, after Pawson harshly adjudged Chester to have handled in the area, McGregor stooped to his right to save Austin's weak effort as Hull shrugged off last season's struggles on the road to begin their campaign in fine fashion.
QPR manager Harry Redknapp: "I was very pleased with how we played today. Some days it just doesn't go your way and to get a penalty late on, to be honest if we'd have scored that we had time to win the game, the momentum was with us. But that's how it goes, some days you get the breaks and some days you don't, I couldn't fault them [the players].
"In the first half we played ever so well, looked in control, good shape, passed it well, created some good chances so it was encouraging. We'll only get better. Rio [Ferdinand] was excellent wasn't he. It was almost a masterclass in how to play at the back. He looked so comfortable, his touch, passing and reading of the game, he's a fantastic footballer."
Hull City manager Steve Bruce: "Snodgrass is a concern. He's twisted his knee. He's in a brace and crutches at the moment. Touch wood he's not too bad, but we fear ligament damage. If it is, of course, it means it's going to be a long time, so let's hope it's not.
"Alex [Bruce] has hurt his back, but we don't think that's too serious."
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